Nordihydroguaiaretic acid - CAS# 500-38-9 481585 Nepafenac inhibits prostaglandin synthesis in

Nepafenac inhibits prostaglandin synthesis in the iris/ciliary body (85-95%) and the retina/choroid (55%) in rabbits

dimerizes with a small Maf protein (sMaf)

wakefulness

2019 May 17

Target: Histamine H1-receptorMizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis)

Nordihydroguaiaretic acid - CAS# 500-38-9 481585 Nepafenac inhibits prostaglandin synthesis inEtrasimod, also known as APD334, is a potent, centrally available, functional antagonists of the S1P1 receptor for use as next generation therapeutics for treating multiple sclerosis (MS) and other autoimmune diseases. APD334 has a favorable PK PD profile, producing robust lymphocyte lowering at relatively low plasma concentrations in several preclinical species. APD334 was efficacious in a mouse experimental autoimmune encephalomyelitis (EAE) model