GSK2578215A - CAS# 1285515-21-0 ptan 40)/t27-/m0/s1
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GSK2578215A - CAS# 1285515-21-0 ptan 40)/t27-/m0/s1GSK2578215A is a potent and highly selective LRRK2 kinase inhibitor. GSK2578215A induces protective autophagy in SH SY5Y cells: involvement of Drp 1 mediated mitochondrial fission and mitochondrial derived ROS signaling. Mutations in the leucine rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson's disease, and its inhibition opens potential new therapeutic options. GSK2578215A induces mitochondrial fragmentation of an early step
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