GSK461364 Size:10mg solid Chemical Name: 1-((2'-(1H-tetrazol-5-yl)-[1

Chemical Name: 1-((2'-(1H-tetrazol-5-yl)-[1

Formula: C21H17N3O2S

Dabrafenib inhibits the release of HMGB1 and downregulates HMGB1-dependent inflammatory responses by enhancing the expressions of cell adhesion molecules (CAMs) in human endothelial cells

Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities

018 L/kg/h)

GSK461364 Size:10mg solid Chemical Name: 1-((2'-(1H-tetrazol-5-yl)-[1GSK 461364 is a Polo like kinase 1 inhibitor, is also a small molecule Polo like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a