BEZ235 - CAS# 915019-65-7 Catalog No.:M10947-10 RJR2403 hemioxalate

RJR2403 hemioxalate

InChiKey: CEMXHAPUFJOOSV-XGWNLRGSSA-N

LD50: Mice 55mg/kg (i

which attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord

Epub 2010 Sep 5

BEZ235 - CAS# 915019-65-7 Catalog No.:M10947-10 RJR2403 hemioxalateDactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3 kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the